(1) Annual report, Centre National des Leptospires, 2008
(2) Vaccination guides, 2006 edition, Directorate General of Health, Technical commitee on vaccinations
(3) Ferguson IR : "A European Perspective on Leptospirosis. Microbiology Europe 1994"; jan-feb:8-11.
(4) Tables for professional diseases
(5) Report of the Working Group of the High Council for Health and Safety, New recommandations for the prevention of risks among people exposed to leptospirosis, a report presented and accepted at the meeting of March 18, 2005.
(6) Department of Agriculture and Fisheries "Leptospirosis"
The marketing department is using IT tools in order to easily manage prescribers of product(s) commercialized by IMAXIO.
The recorded information is reserved for the use of the relevant department and can only be disclosed to medical representatives.
In accordance with the articles 39 and seq of the law n°78-17 of the 6th of January 1978 amended in 2004 relating to data, file and freedom, every person can obtain communication and, if necessary, rectification or deletion of its own information by contacting the marketing department.
Update: December 2012
||IMAXIO markets a vaccine against leptospirosis.
Leptospirosis, a disease still relevant
Leptospirosis is a zoonose with no required statement and probably underestimated. On French territory, nearly 800 cases of leptospirosis contamination were reported in 2009.
Leptospirosis is a potentially serious infectious disease caused by bacteria of the family of Spirochetes (Leptospira, Treponema, Borrelia, Lyme disease and syphilis). Leptospira interrogans is the origin of pathogenic forms and includes several serogroups. In France, Icterohaemorragiae serogroup is dominant (1) and is the agent of the majority of the most severe forms (2).
This bacterium is resistant in a moist environment and can be present in many mammals: livestock (pigs, cows), pets (dogs, horses) and wild animals (hedgehogs, rats, rabbits). Rodents are the main carriers of leptopirosis and are healthy carriers.
In the host organism, bacteria will multiply and spread via the blood to different organs like the liver, lungs or kidneys. Bacteria present in the kidney are removed through the urine, contaminating soil and waterways.
What are the symptoms?
After an incubation period of 4-20 days, clinical expression is manifested by a flu-like syndrome with meningeal symptoms suggesting several diseases. Severe cases progress to kidneys, liver or or multi-visceral problems that can lead to death (5% of cases without treatment). It is therefore important to seek risk activities in order to guide the diagnosis as quickly as possible to provide effective treatment.
Tansmission can be made by:
- directs ways: through contact with animals (dead or alive)
- indirect ways : through contact with contaminated water with the urine of infected animals
Leptospirosis can enter through wounds, mucous membranes (eye, mouth, nose, ...) and even a healthy macerated skin.
Who is at risk?
Leptospirosis is recognized as a professional disease and is listed by the general scheme of the french department of agriculture.
Professional activities at risk:
During freshwater spare time, the risk of contracting the disease is still present. Kayakers, fishermen, cavers are concerned.
For the general population: