IMX313- T Cell Responses Induced by Adenoviral Vectored Vaccines Can Be Adjuvanted by Fusion of Antigen to the Oligomerization Domain of C4b-Binding Protein. Emily K. Forbes, Simone C. de Cassan, David Llewellyn, Sumi Biswas, Anna L. Goodman, Matthew G. Cottingham, Carole A. Long, Richard J. Pleass, Adrian V. S. Hill, Fergal Hill, Simon J. Draper. PLoS ONE. 2012 September;7(9):e44943.
- Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates. Spencer AJ, Hill F, Honeycutt JD, Cottingham MG, Bregu M, Rollier CS, Furze J, Draper SJ, Søgaard KC, Gilbert SC, Wyllie DH, Hill AVS. PLoS ONE. 2012 March;7(3): e33555. doi:10.1371/journal.pone.0033555.
- The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria. Ogun SA, Dumon-Seignovert L, Marchand JB, Holder AA, Hill F. Infect Immun. 2008 Aug;76(8):3817-3823.
- Effective induction of high-titer antibodies by viral vector vaccines. Draper SJ, Moore AC, Goodman AL, Long CA, Holder AA, Gilbert SC, Hill F, Hill AV. Nat Med. 2008 Aug;14(8):819-821.
GENOMICS
-
Rare germline large rearrangements in the BRCA1/2 genes and eight candidate genes in 472 patients with breast cancer predisposition. Rouleau E, Jesson B, Briaux A, Nogues C, Chabaud V, Demange L, Sokolowska J, Coulet F, Barouk-Simonet E, Bonnet F, Bourdon V, Bignon YJ, Bronner M, Castera L, Caputo S, Delnatte C, Delvincourt C, Fournier J, Hardouin A, Muller D, Peyrat JP, Toulas C, Uhrhammer N, Vidal V, Stoppa-Lyonnet D, Bieche I, Lidereau R. Breast Cancer Research and Treatment.
- Comparative clinical and transcriptomal profiles of breast cancer between French and Mediterranean patients show minor but significative biological differences. N. Chalabi, D.J. Bernard-Gallon, Y.-J. Bignon and the Breast Med Consortium : F. Kwiatkowski, M. Agier, V. Vidal, V. Laplace-Chabaud, V. Sylvain-Vidal, V. Bertholet, F. de Longueville, M. Lacroix, G. Leclercq, J. Remacle, C. Sibille, N. Zammateo, N. Ben Jaafar, A. Sefiani, K. Ouldim, A. Mégarbané, N. Jalkh, W. Mahfoudh, W. Troudi, A. Ben Ammar-El Gaïed, L. Chouchane. Cancer Genomics and Proteomics, 5: 2453-262 (2008).
- [ESHG 07] Search for a rapid pre-screening technique to identify heterozygous BRCA mutation carriers using gene expression profiling in peripheral blood lymphocytes. M-L. Vuillaume, N. Uhrhammer, V. Vidal, V. Sylvain Vidal, V. Chabaud, M. Agier and Y-J. Bignon. European Society of Human Genetics, ESHG, Nice, France, 2007.